Vacature PHD Position

Xcontractdownspecialtyclosing-date

• Cardiologie Erasmus MC

• PhD position to study the determinants of skeletal diseases

Join our Genomics research line to study the determinants of skeletal diseases along the life-course

• Closing date 20-03-2024
• 08.15.24.TD1

• 36 hours
• Research university
• Research & Education

• Closing date 20-03-2024
• 08.15.24.TD1

Job description

The primary objective of the project is to enhance our understanding of various types of skeletal fragility and prioritize individuals at fracture risk. More specifically, you will be:

• Integrating information across multiple large-scale data types including genetics, omics, clinical data, and bone properties to gain a comprehensive molecular understanding of skeletal fragility.
• Implementing clustering techniques to identify groups of individuals at heightened risk of osteoporosis and fractures.

You will have access to a large pool of epidemiological data derived from deeply phenotyped population-based and patient-based cohorts with available genetic information. Traditional cluster analysis, pooling risk factors/biomarkers, will be applied to population-based data to identify clusters. In addition, you will apply novel methodologies and platforms integrating large-scale data from distinct -omic (e.g., proteomics, metabolomics), genetics (e.g. GWAS) and clinical (e.g., imaging) sources, to develop new risk stratification and disease clustering strategies, aiming to predict and diagnose people with skeletal fragility at an early stage.

The specific focus will be on developing and validating machine learning (ML)-based stratification system, capable of identifying robust patient clusters at risk or network of biologic pathways associated with skeletal fragility. This effort is expected to drive forward advancements in personalized medicine and improved patient care.

Work environment

You will be working within the Laboratory for Population Genomics at the Internal Medicine department of Erasmus MC. The Research activities within the Laboratory for Population Genomics focus on genetics and genomics of complex traits and common diseases and are assigned to six research lines.

You will be working in Genomics research line under the supervision of Professor Dr. Fernando Rivadeneira and Dr. Katerina Trajanoska. In our research group we study the determinants of skeletal diseases along the life-course (with special focus on osteoporosis), seeking the translation of genomic discoveries into clinical applications. We do this by applying state-of-the art "big data" analytics integrating genomic functional assessments, imaging, and other forms of clinical data. The group has contributed to numerous genomic discoveries in the musculoskeletal field, achieved together with researchers from > 30 countries brought together by the Genetic Factor of Osteoporosis (GEFOS) consortium and the GEnomics of MusculoSkeletal traits TranslatiOnal Network (GEMSTONE-CA-18139) Cost Action. Here you can read more about our group.

Qualifications and skills

We are looking for a PhD candidate with a strong and enthusiastic motivation for a PhD track that combines epidemiology and translational research. You have a positive work attitude and you are able to work both in a project team and independently, taking leadership and responsibility for research tasks. In addition:

• You have a successfully completed MSc degree in health sciences or related fields.
• You have interest and affinity with the fields of musculoskeletal health, genetic epidemiology and data analysis.
• You are willing to learn and expand your computational and programming skills.

Existing computational skills (e.g., shell scripting, R, python) are an advantage. Experience in genetic data analysis, statistics, and machine learning is advantageous but not mandatory. Excellent communication skills, including writing and presentation skills in English (IELTS 7, TOEFL 600, 95 TOEFL internet based) are a prerequisite.

Terms of employment

• You will receive a temporary position for 4 years. The gross monthly salary is € 2.901,- in the 1st year and increases to € 3.677,- in the 4th year (scale OIO).
• Excellent fringe benefits, such as a 13th month that is already paid out in November and a personal travel budget.
• Pension insurance with ABP. The employer covers approximately 2/3 of the monthly contribution.
• Special benefits, such as a physiotherapist and a company bicycle repairer. And there is also a sports club where you can work on your fitness after work.

If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website.

For more information about this position, please contact , Professor Genomics, .

1

Apply

Step 1 - Apply

Did we get you excited about this position? Submit your application through the application button. You will receive a confirmation of receipt from our recruiter right away.

2

Selection

Step 2 - Selection

Based on your application, we check to see if there is a fit between us. We will let you know as soon as possible whether you are invited for an interview.

Step 3 - Job interview

You have been invited for an interview, great! In this first meeting we get to know each other and see if You can form an idea of the position, the department and Erasmus MC. If the interview goes well usually a second interview follows.

Step 4 - Offer and terms of employment

It's a match! Your future manager will discuss your salary and employment with you. You will also receive more information about our other terms of employment.

Step 5 - Getting started

Your first working day has come! We are more than happy to have you. Your new department will give you a warm welcome and provide you with all the information you need. Enjoy your job at Erasmus MC!

Share vacancy

• send email

• send WhatsApp

Erasmus MC

Pioneering, pushing boundaries and leading: in healthcare, education and research

Erasmus MC is an international leading academic hospital in Rotterdam. We are recognized as a world-class scientific research organization aiming to improve our understanding of diseases and disorders and helps to predict, treat and prevent them. We have access to the latest equipment and techniques. A working environment that gets the best out of people.

Apply for PhD position to study the determinants of skeletal diseases

Submit

For information about job opportunities

Contact our Recruitment Team.

Functie:	phd position
Startdatum:	08-03-2024
Ervaring:	Ervaren
Educatielevel:	WO
Contracttype:	Vast
Salaris:	3677 – 3677
Uren per week:	36 – 36

Heb je interesse in deze vacature en wil je graag op deze functie solliciteren? Neem dan contact op met Unknown via Unknown of Unknown. Of bezoek hun website Unknown.